Fibrosis vs. Sclerosis

Fibrosisnoun

(medicine) The formation of (excess) fibrous connective tissue in an organ.

Fibrosisnoun

development of excess fibrous connective tissue in an organ

Fibrosis

Fibrosis, also known as fibrotic scarring, is a pathological wound healing in which connective tissue replaces normal parenchymal tissue to the extent that it goes unchecked, leading to considerable tissue remodelling and the formation of permanent scar tissue.Repeated injuries, chronic inflammation and repair are susceptible to fibrosis where an accidental excessive accumulation of extracellular matrix components, such as the collagen is produced by fibroblasts, leading to the formation of a permanent fibrotic scar.In response to injury, this is called scarring, and if fibrosis arises from a single cell line, this is called a fibroma. Physiologically, fibrosis acts to deposit connective tissue, which can interfere with or totally inhibit the normal architecture and function of the underlying organ or tissue.

Sclerosisnoun

(pathology) The abnormal hardening of body tissues, such as an artery.

Sclerosisnoun

Inability to create change.

Sclerosisnoun

Induration; hardening; especially, that form of induration produced in an organ by increase of its interstitial connective tissue.

Sclerosisnoun

Hardening of the cell wall by lignification.

Sclerosisnoun

any pathological hardening or thickening of tissue