Looking on the internet deeply has found these results:

a difference is the most popular phrase on the web.

2 differences 1819,000 results on the web	a difference 1169,000,000 results on the web More popular!
Some examples and use cases from the internet:	Some examples and use cases from the internet:
It doesn't look like this phrase is very popular! The search could not find any examples on the internet.	There's a difference between cheating with tax... and fleecing a friend. I say there's a difference. It can make a hell of a difference. There's a difference between loyalty and being indebted to someone. There is a difference between snacking and bingeing. With natural ingredients, there is a difference compared to other cosmetic products. What a difference between this and your first draft. There's a difference between risking for yourself and someone else.

2 differences

1819,000 results on the web

a difference

1169,000,000 results on the web

More popular!

It doesn't look like this phrase is very popular! The search could not find any examples on the internet.

There's a difference between cheating with tax... and fleecing a friend.
I say there's a difference.
It can make a hell of a difference.
There's a difference between loyalty and being indebted to someone.
There is a difference between snacking and bingeing.
With natural ingredients, there is a difference compared to other cosmetic products.
What a difference between this and your first draft.
There's a difference between risking for yourself and someone else.