ApoE-KO mice (B6.129P2-Apoetm1Unc/J) vs apoE-KO (B6.129P2-Apoetm1Unc/J) mice

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  • There was an increased incidence of tumours (hepatocellular adenomas) in mice exposed for 2 years to high doses (> 75 times human exposure), but this was considered secondary to prasugrel
  • The Commission intends to examine the possibility of setting up a paediatric study programme: Medicines Investigation for the Children of Europe (MICE), taking into consideration existing Community Programmes.
  • Conventional carcinogenicity rodent studies with low exposures compared to human exposure under therapeutic conditions (factor 0.1 in rats and 1 in mice) did not reveal tumorigenicity of ribavirin.
  • The biological efficacy of epoetin alfa has been demonstrated in various animal models in vivo (normal and anaemic rats, polycythaemic mice).
  • induced enzyme
  • The biological efficacy of erythropoietin has been demonstrated in various animal models in vivo (normal and anaemic rats, polycythaemic mice).
  • The challenge procedure involves the administration of tetanus toxin to guinea pigs (method A) or mice (method B), resulting in paralysis and death.
  • 2.6 The Commission intends to examine the possibility of setting up a paediatric study programme: Medicines Investigation for the Children of Europe (MICE), taking into consideration existing Community Programmes.
  • 15).
  • It is necessary to establish the MICE (Medicines Investigation for the Children of Europe).
  • Cladribine is teratogenic in mice (at doses of 1.5
  • 3.0 mg/ kg/ day, given on gestation days 6
  • After 2 years administration of darunavir at exposures at or below the human exposure, kidney changes were observed in mice (nephrosis) and rats (chronic progressive nephropathy).
  • Air Malta will apply industry standard practices to revenue management, pricing and increasing focus on MICE (Meetings, incentives, conferencing, exhibitions), corporate travel and tour operator relationships.
  • Fertility In fertility studies gemcitabine caused hypospermatogenesis in male mice (see section 5.3).
  • Fertility In fertility studies gemcitabine caused hypospermatogenesis in male mice (see section 5.3).

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