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- Satellite groups may also be included in the chronic toxicity phase of the study, to monitor the reversibility of any toxicological changes induced by the test chemical under investigation.
- dose toxicity tests are intended to reveal any physiological and/or pathological changes induced by repeated administration of the active substance or combination of active substances under examination, and to determine how these changes are related to dosage.
- Satellite groups included to monitor the reversibility of any toxicological changes induced by the test chemical under investigation should be maintained without dosing for a period not less than 4 weeks and not more than one third of the total study duration after cessation of exposure.
- Repeated dose toxicity tests are intended to reveal any physiological and/or anatomo
- pathological changes induced by repeated administration of the active substance or combination of active substances under examination, and to determine how these changes are related to dosage.
- Radiation dose to specific organs, which may not be the target organ of therapy, may be influenced significantly by pathophysiological changes induced by the disease process.
- Repeat
- Satellite groups may also be included to monitor the reversibility of any toxicological changes induced by the test chemical under investigation; these will normally be restricted to the highest dose level of the study plus control.
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- off/write
- The times at which monitoring is undertaken shall be selected so as to minimise the impact of seasonal variation on the results, and thus ensure that the results reflect changes in the water body as a result of changes due to anthropogenic pressure.
- The changes due to food intake are not clinically significant.
- The Member States concerned have not indicated whether they are continuing to apply the exemption beyond 2006 nor have they informed the Commission of any changes to the applicable legislation, in particular changes due to the transposition of Directive 2003/96, that could affect the Commission's assessment.
- Other revaluation adjustments include changes in the price of securities issued, sold or held and changes due to the removal from the balance sheet of loans subject to a write
- down.
- In particular, reclassifications for the year 2001 will need to cover the changes due to the entry of Greece into the euro area.
- Eyelids swollen, with pronounced changes due to decay.
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