Some examples and use cases from the internet:

Some examples and use cases from the internet:

• Isotretinoin and its metabolites do not significantly affect CYP activity.
• Within the maximum indicative budget of each specific action, cumulated changes not exceeding 20 % are not considered to be substantial provided that they do not significantly affect the nature and objectives of the Work Plan.
• It does not serve to include substances which, while having an effect on the human body, do not significantly affect the metabolism and thus do not strictly modify the way in which it functions.
• Adjustments of the programme that do not significantly affect the nature and objectives of the programme shall be considered non substantial.
• Although it is best to include all firms in the calculation, lack of information about very small firms may not be important because such firms do not affect the HHI significantly.
• Cumulated changes of the allocations to the specific actions not exceeding 20 % of the maximum contribution authorised by this Decision are not considered to be substantial provided that they do not significantly affect the nature and objective of the work programme.
• The Commission believes that national systems of fixed book prices, based on agreements between companies, are compatible with Community competition rules if they do not significantly affect trade between Member States.
• The food groups that are not traditionally smoked, such as crisps, soups and sauces, do not significantly affect exposure.

• The food groups that are not traditionally smoked, such as crisps, soups and sauces, do not significantly affect exposure.
• This does not preclude the possibility for Member States to allow a higher mass for either the purpose of carriage of indivisible loads or for the purposes of certain national transport operations that do not significantly affect international competition
• Within the maximum indicative budget of each specific action, cumulated changes not exceeding 20 % are not considered to be substantial provided that they do not significantly affect the nature and objectives of the Work Plan.
• Adjustments of the programme that do not significantly affect the nature and objectives of the programme shall be considered non substantial.
• This does not preclude the possibility for Member States to allow a higher mass either for the purpose of carriage of indivisible loads or for the purposes of certain national transport operations that do not significantly affect international competition in the transport sector,
• Cumulated changes of the allocations to the specific actions not exceeding 20 % of the maximum contribution authorised by this Decision are not considered to be substantial provided that they do not significantly affect the nature and objective of the work programme.
• The Commission believes that national systems of fixed book prices, based on agreements between companies, are compatible with Community competition rules if they do not significantly affect trade between Member States.
• Isotretinoin and its metabolites do not significantly affect CYP activity.