Looking on the internet deeply has found these results:

in spite of is the most popular phrase on the web.

even if 10 results on the web	in spite of 17,020,000 results on the web More popular!
Some examples and use cases from the internet:	Some examples and use cases from the internet:
He can't kill me, even if I turn. Find words even if they are misspelled. They can trace us even if we don't answer. So even if it's difficult, be strong. So fly, even if the door is closed. Persistence stays even if the computer crashes. Civilizations can change even if societies are stable. And even if British cars were terrible...	The English terms despite and in spite of are synonyms. Despite might be a tiny bit more formal, but the two terms are interchangeable. Just be careful not to say ... The prepositions in spite of and despite are exactly the same in all their definitions, and they are usually interchangeable. For writers who value brevity, despite ... in spite of, in disregard or defiance of; notwithstanding; despite: She arrived at school on time in spite of the snowstorm. Origin of spite. Expand. Middle English. In spite of and despite are prepositional expressions. In spite of and despite have a similar meaning to although or even though. They express a contrast ...

even if

10 results on the web

in spite of

17,020,000 results on the web

More popular!

The English terms despite and in spite of are synonyms. Despite might be a tiny bit more formal, but the two terms are interchangeable. Just be careful not to say ...
The prepositions in spite of and despite are exactly the same in all their definitions, and they are usually interchangeable. For writers who value brevity, despite ...
in spite of, in disregard or defiance of; notwithstanding; despite: She arrived at school on time in spite of the snowstorm. Origin of spite. Expand. Middle English.
In spite of and despite are prepositional expressions. In spite of and despite have a similar meaning to although or even though. They express a contrast ...