Looking on the internet deeply has found these results:

in times of trouble is the most popular phrase on the web.

in time of trouble 1468,000 results on the web	in times of trouble 1566,000 results on the web More popular!
Some examples and use cases from the internet:	Some examples and use cases from the internet:
Everybody loves a witty doctor in times of trouble. abandoned faith in time of trouble? You turning back to your long In times of trouble, family must stick together. abandoned faith in time of trouble? You turning back to your long In times of trouble we should be together. God, who is that very present help... in time of trouble.	What a blessing distant relations are in times of trouble. Everybody loves a witty doctor in times of trouble. Helps me and others focus in times of trouble. In times of trouble we should be together. Mr President, with respect to the floods, it could be said that, in times of trouble, you find out who your friends are. The Club will make room we'll trim the guest list, austerity in times of trouble... You're always here for me in times of trouble. In times of trouble, I hear her voice giving me advice.

in time of trouble

1468,000 results on the web

in times of trouble

1566,000 results on the web

More popular!

What a blessing distant relations are in times of trouble.
Everybody loves a witty doctor in times of trouble.
Helps me and others focus in times of trouble.
In times of trouble we should be together.
Mr President, with respect to the floods, it could be said that, in times of trouble, you find out who your friends are.
The Club will make room we'll trim the guest list, austerity in times of trouble...
You're always here for me in times of trouble.
In times of trouble, I hear her voice giving me advice.