Looking on the internet deeply has found these results:

no problem with is the most popular phrase on the web.

no problem in 112,900,000 results on the web	no problem with 143,300,000 results on the web More popular!
Some examples and use cases from the internet:	Some examples and use cases from the internet:
There is definitely no problem in substance. I have no problem in using the weapon. In other words, there is no problem in this respect. There's no problem in swimming or diving. No problem in the tower, is there? With this partial modification we have no problem in accepting it. The irony is that on this particular occasion it is being offered as a solution to an area for which there is no problem in the first place. I see no problem in continuing our common reflection in this regard.	I had no problem with space stuff. I have no problem with my vocation. I have no problem with... unexpected. I have no problem with lactose. Mmm. I have no problem with... He has no problem with us. I hope there's no problem with the treasury. I've got no problem with you.

no problem in

112,900,000 results on the web

no problem with

143,300,000 results on the web

More popular!

There is definitely no problem in substance.
I have no problem in using the weapon.
In other words, there is no problem in this respect.
There's no problem in swimming or diving.
No problem in the tower, is there?
With this partial modification we have no problem in accepting it.
The irony is that on this particular occasion it is being offered as a solution to an area for which there is no problem in the first place.
I see no problem in continuing our common reflection in this regard.