Looking on the internet deeply has found these results:

one of the most handsome is the most popular phrase on the web.

one of the handsomest 11,600,000 results on the web	one of the most handsome 11,810,000 results on the web More popular!
Some examples and use cases from the internet:	Some examples and use cases from the internet:
You're the handsomest woman I ever saw. lookin' one. You're the handsomest cowboy in the parade,... ...the best For many months now I have considered her one of the handsomest women of my acquaintance. Promise me you didn't just hire the handsomest one. He was the handsomest boy around me. He's one of the handsomest men on earth, and he's intelligent, and brilliant at acting, and rich. 110 yards deep and is said to be one of the handsomest pits in the county.	Just like the one Handsome Bobby was stuffed into before someone painted it green. Take one of your handsome young men with you. That is one handsome man she's with. Heh. Moses was one of the most handsome men in Maralai. And he knew it. Ma'am from Webster was one handsome lady. Love and position in one handsome package. Telling me that I look like one of the most handsome men in politics does not hurt my feelings, Winston. You are leaving out one handsome variable.

one of the handsomest

11,600,000 results on the web

one of the most handsome

11,810,000 results on the web

More popular!

You're the handsomest woman I ever saw.
lookin' one.
You're the handsomest cowboy in the parade,... ...the best
For many months now I have considered her one of the handsomest women of my acquaintance.
Promise me you didn't just hire the handsomest one.
He was the handsomest boy around me.
He's one of the handsomest men on earth, and he's intelligent, and brilliant at acting, and rich.
110 yards deep and is said to be one of the handsomest pits in the county.

Just like the one Handsome Bobby was stuffed into before someone painted it green.
Take one of your handsome young men with you.
That is one handsome man she's with. Heh.
Moses was one of the most handsome men in Maralai. And he knew it.
Ma'am from Webster was one handsome lady.
Love and position in one handsome package.
Telling me that I look like one of the most handsome men in politics does not hurt my feelings, Winston.
You are leaving out one handsome variable.