Looking on the internet deeply has found these results:

significantly optimized is the most popular phrase on the web.

substantionally optimized 14 results on the web	significantly optimized 122,100 results on the web More popular!
Some examples and use cases from the internet:	Some examples and use cases from the internet:
The baseline parameter's been optimized. Optimized hardware acceleration of OpenGL with nvidia graphic cards Then I calculated the seating position From which each thief could have optimized his Or her stealing opportunity. A workspace optimized for traditional desktops and laptop computers. A codec optimized for high quality speech at low bit rate. No, that page isn't optimized for cell phone use... Reintegration with optimized integration parameters should be possible. The KDE workspace application optimized for Netbook devices.	Reintegration with optimized integration parameters should be possible. The KDE workspace application optimized for Netbook devices. Optimized hardware acceleration of OpenGL with nvidia graphic cards A workspace optimized for traditional desktops and laptop computers. No, that page isn't optimized for cell phone use... A codec optimized for high quality speech at low bit rate. The baseline parameter's been optimized. Then I calculated the seating position From which each thief could have optimized his Or her stealing opportunity.

substantionally optimized

14 results on the web

significantly optimized

122,100 results on the web

More popular!

The baseline parameter's been optimized.
Optimized hardware acceleration of OpenGL with nvidia graphic cards
Then I calculated the seating position From which each thief could have optimized his Or her stealing opportunity.
A workspace optimized for traditional desktops and laptop computers.
A codec optimized for high quality speech at low bit rate.
No, that page isn't optimized for cell phone use...
Reintegration with optimized integration parameters should be possible.
The KDE workspace application optimized for Netbook devices.

Reintegration with optimized integration parameters should be possible.
The KDE workspace application optimized for Netbook devices.
Optimized hardware acceleration of OpenGL with nvidia graphic cards
A workspace optimized for traditional desktops and laptop computers.
No, that page isn't optimized for cell phone use...
A codec optimized for high quality speech at low bit rate.
The baseline parameter's been optimized.
Then I calculated the seating position From which each thief could have optimized his Or her stealing opportunity.