Estimated parameters vs the estimated parameters

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  • Also the size of the standard error or confidence limit around the estimated parameters may be indicative of the goodness of fit of the model.
  • each parameter is estimated for each group of vessels as defined in Appendix III,
  • In general, febuxostat pharmacokinetic parameters estimated by these analyses are consistent with those obtained from healthy subjects, indicating that healthy subjects are representative for pharmacokinetic/ pharmacodynamic assessment in the patient population with gout.
  • is the estimated variance of the estimator of parameter ?.
  • Pharmacokinetic parameters estimated by the model were very close to those estimated from phase I studies.
  • a bilaterally agreed parameter time period before the estimated time at the coordination point, or
  • When showing compliance with (a) to (c), account shall be taken of the appropriate parameters of CAT.POL.H.(c) for the estimated time of landing at the destination aerodrome or operating site, or any alternate if required.
  • The linear clearance was estimated as a parameter in the population pharmacokinetic analysis and was 12.5 ml/ h.
  • The linear clearance was estimated as a parameter in the population pharmacokinetic analysis and was 12.5 ml/ h.
  • is the estimated variance of the estimator of parameter ?.
  • Also the size of the standard error or confidence limit around the estimated parameters may be indicative of the goodness of fit of the model.
  • Pharmacokinetic parameters estimated by the model were very close to those estimated from phase I studies.
  • Based on a limited number of patients, interindividual variability calculated as the coefficient of variation (CV%), was estimated to be approximately 30% for the main pharmacokinetic parameters.
  • each parameter is estimated for each group of vessels as defined in Appendix III,
  • The basal disposition parameters (CL and V) could not be estimated due to the lack of intravenous study.
  • In general, febuxostat pharmacokinetic parameters estimated by these analyses are consistent with those obtained from healthy subjects, indicating that healthy subjects are representative for pharmacokinetic/ pharmacodynamic assessment in the patient population with gout.

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