Looking on the internet deeply has found these results:

there is a big difference is the most popular phrase on the web.

there is a profound difference 14,190 results on the web	there is a big difference 114,900,000 results on the web More popular!
Some examples and use cases from the internet:	Some examples and use cases from the internet:
"There is a profound difference between management and leadership, and both are important. To manage means to bring about, to accomplish, to have charge ... There is a profound difference between information and meaning. Warren Bennis . Biography. Author Profession: Writer. Nationality: American. Born: March 8 ... Sep 29, 2012 ... “There is a profound difference between management and leadership, and both are important. To manage means to bring about, to accomplish ... Aug 11, 2010 ... He wrote in Learning to Lead: A Workbook on Becoming a Leader that “There is a profound difference between management and leadership, ...	It doesn't look like this phrase is very popular! The search could not find any examples on the internet.

there is a profound difference

14,190 results on the web

there is a big difference

114,900,000 results on the web

More popular!

"There is a profound difference between management and leadership, and both are important. To manage means to bring about, to accomplish, to have charge ...
There is a profound difference between information and meaning. Warren Bennis . Biography. Author Profession: Writer. Nationality: American. Born: March 8 ...
Sep 29, 2012 ... “There is a profound difference between management and leadership, and both are important. To manage means to bring about, to accomplish ...
Aug 11, 2010 ... He wrote in Learning to Lead: A Workbook on Becoming a Leader that “There is a profound difference between management and leadership, ...

It doesn't look like this phrase is very popular! The search could not find any examples on the internet.